In Progress
Research Articles
KMT2D is a novel regulator of chemotherapy response in pancreatic cancer.
Raja Arul GL, Tolosa EJ, Sigafoos AN, Pease DR, Petit J, Brown M, Almada LL, Hogenson TL, Graham RP, Meroueh C, Hagen C, Barrett M, Matveyenko A, Carr RM, Ge K, Fernandez-Zapico ME. Life Science Alliance. Revision in progress.
A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function.
Schlesinger D, Dirks C, Navarro CL, Lafranchi L, Spinner A, Raja Arul GL, M-S Tong G, Eirich J, Martinez T, Elsässer SJ. Cell. Revision in progress.
Raja Arul GL, Tolosa EJ, Sigafoos AN, Pease DR, Petit J, Brown M, Almada LL, Hogenson TL, Graham RP, Meroueh C, Hagen C, Barrett M, Matveyenko A, Carr RM, Ge K, Fernandez-Zapico ME. Life Science Alliance. Revision in progress.
A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function.
Schlesinger D, Dirks C, Navarro CL, Lafranchi L, Spinner A, Raja Arul GL, M-S Tong G, Eirich J, Martinez T, Elsässer SJ. Cell. Revision in progress.
Published
Research Articles
KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.
Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, Smyrk TC, Zhang L, Rabe KG, Oberg AL, Zaphiropoulos PG, Chevet E, Graham RP, Hagen CE, di Magliano MP, Elsawa SF, Pin CL, Mao J, McWilliams RR, Fernandez-Zapico ME. Cancer Res Commun. 2024 Jul 1;4(7):1677-1689. doi: 10.1158/2767-9764.CRC-23-0464. PMID: 38896052.
SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer.
Paradise BD, Gainullin VG, Almada LL, Sigafoos AN, Sen S, Vera RE, Raja Arul GL, Toruner M, Pease DR, Gonzalez AL, Mentucci FM, Grasso DH, Fernandez-Zapico ME. Biochem J. 2023 Aug 16;480(15):1199-1216. doi: 10.1042/BCJ20220439. PMID: 37477952.
GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1.
Almada LL, Barroso K, Sen S, Toruner M, Sigafoos AN, Raja Arul GL, Pease DR, Vera RE, Olson RLO, Auner HW, Pedeux R, Iovanna JL, Chevet E, Fernandez-Zapico ME. Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194924. doi: 10.1016/j.bbagrm.2023.194924. Epub 2023 Feb 25. PMID: 36842643.
Prenatal bisphenol-A exposure altered exploratory and anxiety-like behaviour and induced non-monotonic, sex-specific changes in the cortical expression of CYP19A1, BDNF and intracellular signaling proteins in F1 rats.
Raja GL, Lite C, Subhashree KD, Santosh W, Barathi S. Food Chem Toxicol. 2020 Aug;142:111442. doi: 10.1016/j.fct.2020.111442. Epub 2020 May 22. PMID: 32450286.
Transient exposure of methylparaben to zebrafish (Danio rerio) embryos altered cortisol level, acetylcholinesterase activity and induced anxiety-like behaviour.
Raja GL, Divya Subhashree K, Lite C, Santosh W, Barathi S. Gen Comp Endocrinol. 2019 Aug 1;279:53-59. doi: 10.1016/j.ygcen.2018.11.001. Epub 2018 Nov 2. PMID: 30395803.
Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, Smyrk TC, Zhang L, Rabe KG, Oberg AL, Zaphiropoulos PG, Chevet E, Graham RP, Hagen CE, di Magliano MP, Elsawa SF, Pin CL, Mao J, McWilliams RR, Fernandez-Zapico ME. Cancer Res Commun. 2024 Jul 1;4(7):1677-1689. doi: 10.1158/2767-9764.CRC-23-0464. PMID: 38896052.
SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer.
Paradise BD, Gainullin VG, Almada LL, Sigafoos AN, Sen S, Vera RE, Raja Arul GL, Toruner M, Pease DR, Gonzalez AL, Mentucci FM, Grasso DH, Fernandez-Zapico ME. Biochem J. 2023 Aug 16;480(15):1199-1216. doi: 10.1042/BCJ20220439. PMID: 37477952.
GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1.
Almada LL, Barroso K, Sen S, Toruner M, Sigafoos AN, Raja Arul GL, Pease DR, Vera RE, Olson RLO, Auner HW, Pedeux R, Iovanna JL, Chevet E, Fernandez-Zapico ME. Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194924. doi: 10.1016/j.bbagrm.2023.194924. Epub 2023 Feb 25. PMID: 36842643.
Prenatal bisphenol-A exposure altered exploratory and anxiety-like behaviour and induced non-monotonic, sex-specific changes in the cortical expression of CYP19A1, BDNF and intracellular signaling proteins in F1 rats.
Raja GL, Lite C, Subhashree KD, Santosh W, Barathi S. Food Chem Toxicol. 2020 Aug;142:111442. doi: 10.1016/j.fct.2020.111442. Epub 2020 May 22. PMID: 32450286.
Transient exposure of methylparaben to zebrafish (Danio rerio) embryos altered cortisol level, acetylcholinesterase activity and induced anxiety-like behaviour.
Raja GL, Divya Subhashree K, Lite C, Santosh W, Barathi S. Gen Comp Endocrinol. 2019 Aug 1;279:53-59. doi: 10.1016/j.ygcen.2018.11.001. Epub 2018 Nov 2. PMID: 30395803.
Reviews
Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer.
LaRue-Nolan KC, Raja Arul GL, Sigafoos AN, Shi J, Fernandez-Zapico ME. Biochem J. 2024 Aug 7;481(15):983-997. doi: 10.1042/BCJ20230374. PMID: 39078225.
Ecoevolutionary biology of pancreatic ductal adenocarcinoma.
Raja Arul GL, Toruner MD, Gatenby RA, Carr RM. Pancreatology. 2022 Sep;22(6):730-740. doi: 10.1016/j.pan.2022.06.005. Epub 2022 Jul 6. PMID: 35821188.
In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects.
Lite C, Raja GL, Juliet M, Sridhar VV, Subhashree KD, Kumar P, Chakraborty P, Arockiaraj J. Environ Toxicol Pharmacol. 2022 Jan;89:103779. doi: 10.1016/j.etap.2021.103779. Epub 2021 Nov 27. PMID: 34843942.
In utero exposure to endocrine disruptors and developmental neurotoxicity: Implications for behavioural and neurological disorders in adult life.
Raja GL, Subhashree KD, Kantayya KE. Environ Res. 2022 Jan;203:111829. doi: 10.1016/j.envres.2021.111829. Epub 2021 Aug 3. PMID: 34358505.
LaRue-Nolan KC, Raja Arul GL, Sigafoos AN, Shi J, Fernandez-Zapico ME. Biochem J. 2024 Aug 7;481(15):983-997. doi: 10.1042/BCJ20230374. PMID: 39078225.
Ecoevolutionary biology of pancreatic ductal adenocarcinoma.
Raja Arul GL, Toruner MD, Gatenby RA, Carr RM. Pancreatology. 2022 Sep;22(6):730-740. doi: 10.1016/j.pan.2022.06.005. Epub 2022 Jul 6. PMID: 35821188.
In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects.
Lite C, Raja GL, Juliet M, Sridhar VV, Subhashree KD, Kumar P, Chakraborty P, Arockiaraj J. Environ Toxicol Pharmacol. 2022 Jan;89:103779. doi: 10.1016/j.etap.2021.103779. Epub 2021 Nov 27. PMID: 34843942.
In utero exposure to endocrine disruptors and developmental neurotoxicity: Implications for behavioural and neurological disorders in adult life.
Raja GL, Subhashree KD, Kantayya KE. Environ Res. 2022 Jan;203:111829. doi: 10.1016/j.envres.2021.111829. Epub 2021 Aug 3. PMID: 34358505.
Books
Crosstalk between histone modifications integrates various signaling inputs to fine tune transcriptional output.
LaRue Nolan K, Pease DR, Raja Arul GL, Tader BR, Nagarajan S, Johnsen SA. Chromatin Signaling and Diseases. Academic Press. ISBN: 9780443190018.
LaRue Nolan K, Pease DR, Raja Arul GL, Tader BR, Nagarajan S, Johnsen SA. Chromatin Signaling and Diseases. Academic Press. ISBN: 9780443190018.
Editorials
PI3Kα targeting, nipping pancreatic cancer evolution in the bud.
Raja Arul GL, Fernandez-Zapico ME. EMBO Mol Med. 2021 Jul 7;13(7):e14362. doi: 10.15252/emmm.202114362. Epub 2021 May 31. PMID: 34057823.
Raja Arul GL, Fernandez-Zapico ME. EMBO Mol Med. 2021 Jul 7;13(7):e14362. doi: 10.15252/emmm.202114362. Epub 2021 May 31. PMID: 34057823.
